I dati del Registro Tumori della Regione Toscana vengono utilizzati per studi, anche in froma collaborativa, nazionali e internazionali, i cui risultati sono pubblicati in riviste scientifiche:

Pubblicazioni 2012

Verhoeven RH, Gondos A, Janssen-Heijnen ML, Saum KU, Brewster DH, Holleczek B, Crocetti E, Rosso S, Hakulinen T, Aareleid T, Brenner H; EUNICE Survival Working Group Testicular cancer in Europe and the USA: survival still rising among older patients. Ann Oncol. 2012 Oct 30.
PubMed

Caldarella A, Puliti D, Crocetti E, Bianchi S, Vezzosi V, Apicella P, Biancalani M, Giannini A, Urso C, Zolfanelli F, Paci E. Biological characteristics of interval cancers: a role for biomarkers in the breast cancer screening. J Cancer Res Clin Oncol. 2012 Sep 9.
PubMed

Allemani C, Sant M, Weir HK, Richardson LC, Baili P, Storm H, Siesling S, Torrella-Ramos A, Voogd AC, Aareleid T, Ardanaz E, Berrino F, Bielska-Lasota M, Bolick S, Cirilli C, Colonna M, Contiero P, Cress R, Crocetti E, Fulton JP, Grosclaude P, Hakulinen T, Izarzugaza MI, Malmström P, Peignaux K, Primic-Žakelj M, Rachtan J, Diba CS, Sánchez MJ, Schymura MJ, Shen T, Traina A, Tryggvadottir L, Tumino R, Velten M, Vercelli M, Wolf HJ, Woronoff AS, Wu X, Coleman MP. Breast cancer survival in the US and Europe: A CONCORD high-resolution study. Int J Cancer. 2012 Jul 20. doi: 10.1002/ijc.27725.
PubMed

Guzzinati S, Buzzoni C, De Angelis R, Rosso S, Tagliabue G, Vercelli M, Pannozzo F, Mangone L, Piffer S, Fusco M, Giacomin A, Traina A, Capocaccia R, Dal Maso L, Crocetti E; AIRTUM working group. Cancer prevalence in Italy: an analysis of geographic variability. Cancer Causes Control. 2012 Sep;23(9):1497-510. Epub 2012 Jul 21.
PubMed

Crocetti E, Buzzoni C, Caldarella A, Intrieri T, Manneschi G, Sacchettini C, Paci E, Miccinesi G. Suicide mortality among cancer patients. Epidemiol Prev. 2012 Mar-Apr;36(2):83-7.
PubMed

Castaing M, Bella F, Buzzoni C; AIRTUM Working Group. Incidence of stomach cancer is decreasing faster in the Centre-North of Italy. Epidemiol Prev. 2012 Mar-Apr;36(2):129.
PubMed

Caldarella A, Amunni G, Angiolini C, Crocetti E, Di Costanzo F, Di Leo A, Giusti F, Pegna AL, Mantellini P, Luzzatto L, Paci E. Feasibility of evaluating quality cancer care using registry data and electronic health records: a population-based study. Int J Qual Health Care. 2012 May 16.
PubMed

IMPACT WORKING Group. Epidemiological changes in breast tumours in Italy: the IMPACT study on mammographic screening programmes. Pathologica. 2011 Oct;103(5):290-3.
PubMed

Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Páez A, Määttänen L, Bangma CH, Aus G, Carlsson S, Villers A, Rebillard X, van der Kwast T, Kujala PM, Blijenberg BG, Stenman UH, Huber A, Taari K, Hakama M, Moss SM, de Koning HJ, Auvinen A; ERSPC Investigators. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012 Mar 15;366(11):981-90. Erratum in: N Engl J Med. 2012 May 31;366(22):2137.
PubMed

Crocetti E, Buzzoni C, Chiarugi A, Nardini P, Pimpinelli N. Relationship between Latitude and Melanoma in Italy. ISRN Oncol. 2012;2012:864680. Epub 2012 Jan 16.
PubMed

Oberaigner W, Minicozzi P, Bielska-Lasota M, Allemani C, de Angelis R, Mangone L, Sant M; Eurocare Working Group. Survival for ovarian cancer in Europe: the across-country variation did not shrink in the past decade. Acta Oncol. 2012 Apr;51(4):441-53. Epub 2012 Feb 7.
PubMed

Trama A, Mallone S, Nicolai N, Necchi A, Schaapveld M, Gietema J, Znaor A, Ardanaz E, Berrino F; RARECARE Working Group. Burden of testicular, paratesticular and extragonadal germ cell tumours in Europe. Eur J Cancer. 2012 Jan;48(2):159-69. Epub 2011 Dec 3.
PubMed

Puliti D, Miccinesi G, Zappa M, Manneschi G, Crocetti E, Paci E. Balancing harms and benefits of service mammography screening programs: a cohort study. Breast Cancer Res. 2012 Jan 9;14(1):R9.
PubMed

Crocetti E, Trama A, Stiller C, Caldarella A, Soffietti R, Jaal J, Weber DC, Ricardi U, Slowinski J, Brandes A; RARECARE working group. Epidemiology of glial and non-glial brain tumours in Europe. Eur J Cancer. 2012 Jan 6.
PubMed

Lise M, Franceschi S, Buzzoni C, Zambon P, Falcini F, Crocetti E, Serraino D, Iachetta F, Zanetti R, Vercelli M, Ferretti S, La Rosa F, Donato A, De Lisi V, Mangone L, Busco S, Tagliabue G, Budroni M, Bisanti L, Fusco M, Limina RM, Tumino R, Piffer S, Madeddu A, Bellù F, Giacomin A, Candela G, Anulli ML, Dal Maso For Airtum Working Group L. Changes in the incidence of thyroid cancer between 1991 and 2005 in Italy: a geographical analysis. Thyroid. 2012 Jan;22(1):27-34.
PubMed

Pubblicazioni 2011

AIRTUM Working Group. Italian cancer figures, report 2011: Survival of cancer patients in Italy. Epidemiol Prev. 2011 Sep-Dec;35(5-6 Suppl 3):1-200.
PubMed

Manneschi G, Crocetti E, Puliti D, Zappa M, Sacchettini C, Paci E. Cancer incidence in Italian natives and in first-generation immigrants to Italy. Epidemiol Prev. 2011 Sep;35(5-6):292-6.
PubMed

Buzzoni C, Zappa M, Marchi M, Caldarella A, Corbinelli A, Giusti F, Intrieri T, Manneschi G, Nemcova L, Sacchettini C, Crocetti E. Socio-economic determinants of cancer survival in the municipality of Florence. Epidemiol Prev. 2011 Sep;35(5-6):267-74.
PubMed

Buzzoni C; AIRTUM Working Group. Population ageing effect on number of cancer cases: Italian cancer registries data. Epidemiol Prev. 2011 May-Aug;35(3-4):216-21.
PubMed

Turco P, Houssami N, Bulgaresi P, Troni GM, Galanti L, Cariaggi MP, Cifarelli P, Crocetti E, Ciatto S. Is conventional urinary cytology still reliable for diagnosis of primary bladder carcinoma? Accuracy based on data linkage of a consecutive clinical series and cancer registry. Acta Cytol. 2011;55(2):193-6. Epub 2011 Feb 15.
PubMed

Caldarella A, Crocetti E, Paci E. Is the incidence of brain tumors really increasing? A population-based analysis from a cancer registry. J Neurooncol. 2011 Sep;104(2):589-94. Epub 2011 Feb 17.
PubMed

Marcos-Gragera R, Allemani C, Tereanu C, De Angelis R, Capocaccia R, Maynadie M, Luminari S, Ferretti S, Johannesen TB, Sankila R, Karjalainen-Lindsberg ML, Simonetti A, Martos MC, Raphaël M, Giraldo P, Sant M; HAEMACARE Working Group. Survival of European patients diagnosed with lymphoid neoplasms in 2000-2002: results of the HAEMACARE project. Haematologica. 2011 May;96(5):720-8. Epub 2011 Feb 17.
PubMed

Crocetti E, Caldarella A, Chiarugi A, Nardini P, Zappa M. Does in situ melanoma really come before invasive melanoma? Descriptive epidemiology questions this relationship. Tumori. 2011 Mar-Apr;97(2):257. doi: 10.1700/667.7797
PubMed

Puliti D, Miccinesi G, Manneschi G, Buzzoni C, Crocetti E, Paci E, Zappa M. Does an organised screening programme reduce the inequalities in breast cancer survival? Ann Oncol. 2011 Apr 22. [Epub ahead of print]
PubMed

Caldarella A, Crocetti E, Paci E. Distribution, Incidence, and Prognosis in Neuroendocrine Tumors: a Population Based Study from a Cancer Registry. Pathol Oncol Res. 2011 Apr 9.
PubMed

Caldarella A, Crocetti E, Bianchi S, Vezzosi V, Urso C, Biancalani M, Zappa M. Female Breast Cancer Status According to ER, PR and HER2 Expression: A Population Based Analysis. Pathol Oncol Res. 2011 Apr 10.
PubMed

Pubblicazioni 2010

Zigon G, Berrino F, Gatta G, Sánchez MJ, van Dijk B, Van Eycken E, Francisci S; EUROCARE Working Group. Prognoses for head and neck cancers in Europe diagnosed in 1995-1999: a population-based study. Ann Oncol. 2011 Jan;22(1):165-74. Epub 2010 Jun 29.
PubMed

AIRTUM Working Group. Italian cancer figures, report 2010: Cancer prevalence in Italy. Patients living with cancer, long-term survivors and cured patients. Epidemiol Prev. 2010 Sep-Dec;34(5-6 Suppl 2):1-188. English, Italian.
PubMed

Crocetti E, Buzzoni C; AIRTUM Working Group. Numbers: Italy is one of the European countries with the greatest population observed by Cancer Registries. Epidemiol Prev. 2010 Sep-Dec;34(5-6):82.
PubMed

Dal Maso L, Lise M, Zambon P, Falcini F, Crocetti E, Serraino D, Cirilli C, Zanetti R, Vercelli M, Ferretti S, Stracci F, De Lisi V, Busco S, Tagliabue G, Budroni M, Tumino R, Giacomin A, Franceschi S; for AIRTUM Working Group. Incidence of thyroid cancer in Italy, 1991-2005: time trends and age-period-cohort effects. Ann Oncol. 2010 Oct 15.
PubMed

Rosso S, Gondos A, Zanetti R, Bray F, Zakelj M, Zagar T, Smailyte G, Ponti A, Brewster DH, Voogd AC, Crocetti E, Brenner H; the EUNICE Survival Working Group. Up-to-date estimates of breast cancer survival for the years 2000-2004 in 11 European countries: The role of screening and a comparison with data from the United States. Eur J Cancer. 2010 Oct 11.
PubMed

Crocetti E, Buzzoni C; AIRTUM Working Group.Numbers: Colorectal cancer: if the actual trend persists, the gap between North and South will disappear in 2019Acute effects of air pollution in Brindisi (Italy): Epidemiol Prev. 2010 May-Jun;34(3):69.
PubMed

Crocetti E, Buzzoni C, Zappa M. Colorectal cancer incidence rates have decreased in central Italy. Eur J Cancer Prev. 2010 Nov;19(6):424-5.
PubMed

Crocetti E, Caldarella A, Chiarugi A, Nardini P, Zappa M. The thickness of melanomas has decreased in central Italy, but only for thin melanomas, while thick melanomas are as thick as in the past. Melanoma Res. 2010 Jul 31.
PubMed

Crocetti E, Manneschi G, Visioli CB, Zappa M. Risk of invasive cervical cancer and cervical intraepithelial neoplasia grade III in central Italy by area of birth. J Med Screen. 2010;17(2):87-90.
PubMed

Crocetti E, Buzzoni C; AIRTUM Working Group. Numbers. Childhood cancer: after the peak reached around 2000 the incidence seems to stabilize. Epidemiol Prev. 2010 Jan-Apr;34(1-2):4.
PubMed

Crocetti E, Buzzoni C, Falcini F, Cortesi L, De Lisi V, Ferretti S, Tumino R, Russo A, Paci E. Disentangling the Roles of Mammographic Screening and HRT in Recent Breast Cancer Incidence Trends in Italy by Analyses Based on Calendar Time and Time Since Screening Activation. Breast J. 2010 Apr 23.
PubMed

Allemani C, Storm H, Voogd AC, Holli K, Izarzugaza I, Torrella-Ramos A, Bielska-Lasota M, Aareleid T, Ardanaz E, Colonna M, Crocetti E, Danzon A, Federico M, Garau I, Grosclaude P, Hédelin G, Martinez-Garcia C, Peignaux K, Plesko I, Primic-Zakelj M, Rachtan J, Tagliabue G, Tumino R, Traina A, Tryggvadóttir L, Vercelli M, Sant M. Variation in 'standard care' for breast cancer across Europe: A EUROCARE-3 high resolution study. Eur J Cancer. 2010 Mar 16.
PubMed

Bouvier AM, Sant M, Verdecchia A, Forman D, Damhuis R, Willem Coebergh J, Crocetti E, Crosignani P, Gafa L, Launoy G, Martinez-Garcia C, Plesko I, Pompe-Kirn V, Rachtan J, Velten M, Vercelli M, Zwierko M, Esteve J, Faivre J. What reasons lie behind long-term survival differences for gastric cancer within Europe? Eur J Cancer. 2010 Feb 15.
PubMed

Crocetti E, Ciatto S, Buzzoni C, Zappa M. Prostate cancer incidence rates have started to decrease in central Italy. J Med Screen. 2010;17(1):50-1.
PubMed

Lepage C, Ciccolallo L, De Angelis R, Bouvier A, Faivre J, Gatta G; and the EUROCARE working group. European disparities in malignant digestive endocrine tumours survival. Int J Cancer. 2010 Jun 15.
PubMed

Lepage C, Sant M, Verdecchia A, Forman D, Esteve J, Faivre J; and the EUROCARE working group. Operative mortality after gastric cancer resection and long-term survival differences across Europe. Br J Surg. 2010 Feb;97(2):235-9.
PubMed

Polesel J, Franceschi S, Suligoi B, Crocetti E, Falcini F, Guzzinati S, Vercelli M, Zanetti R, Tagliabue G, Russo A, Luminari S, Stracci F, De Lisi V, Ferretti S, Mangone L, Budroni M, Limina RM, Piffer S, Serraino D, Bellù F, Giacomin A, Donato A, Madeddu A, Vitarelli S, Fusco M, Tessandori R, Tumino R, Piselli P, Dal Maso L; for the Cancer AIDS Registries (CARL) StudyCancer and AIDS Registry Linkage Study: Mauro Lise, Antonella Zucchetto, Angela De Paoli (Centro di Riferimento Oncologico, Aviano); Teresa Intrieri (Tuscany Cancer Registry); Rosa Vattiato (Romagna Cancer Registry, Meldola); Paola Zambon (Veneto Cancer Registry); Antonella Puppo (Liguria Cancer Registry); Silvia Patriarca (Piedmont Cancer Registry, City of Torino); Andrea Tittarelli (Lombardia Cancer Registry, Varese Province); Mariangela Autelitano (Cancer Registry of Milan); Claudia Cirilli (Modena Cancer Registry); Francesco La Rosa (Umbria Cancer Registry); Paolo Sgargi (Parma Province Cancer Registry); Enza Di Felice (Reggio Emilia Cancer Registry); Rosaria Cesaraccio (Cancer Registry of Sassari); Francesco Donato (Brescia Health Unit Cancer Registry); Silva Franchini (Trento Cancer Registry); Loris Zanier (Friuli Venezia Giulia Cancer Registry); Fabio Vittadello (Alto Adige/Sudtitol Cancer Registry); Pier Carlo Vercellino (Piedmont Cancer Registry, Province of Biella); Gennaro Senatore (Salerno Cancer Registry); Maria Lia Contrino (Syracuse Province Registry of Pathology); Silvia Antonini (Macerata Cancer Registry); Raffaele Palombino (Campania Cancer Registry); Sergio Maspero (Sondrio Cancer Registry); Maria Guglielmina La Rosa (Ragusa Cancer Registry); Laura Camoni, Vincenza Regine (National Institute of Health, Rome). Cancer incidence in people with AIDS in Italy. Int J Cancer. 2010 Jan 4.
PubMed

Pubblicazioni 2009

Alvaro D, Crocetti E, Ferretti S, Bragazzi MC, Capocaccia R; the AISF “Cholangiocarcinoma” committee Descriptive epidemiology of cholangiocarcinoma in Italy. Dig Liver Dis 2009 Dec 18 Epub
PubMed

Berrino F, Verdecchia A, Lutz JM, Lombardo C, Micheli A, Capocaccia R; EUROCARE Working Group. Comparative cancer survival information in Europe. Eur J Cancer. 2009 Apr;45(6):901-8.
PubMed

Brenner H, Francisci S, de Angelis R, Marcos-Gragera R, Verdecchia A, Gatta G, Allemani C, Ciccolallo L, Coleman M, Sant M; EUROCARE Working Group. Long-term survival expectations of cancer patients in Europe in 2000-2002. Eur J Cancer. 2009 Apr;45(6):1028-41. Epub 2008 Dec 16.
PubMed

Capocaccia R, Martina L, Inghelmann R, Crocetti E, De Lisi V, Falcini F, Guzzinati S, Rosso S, Tagliabue G, Tumino R, Vercelli M, Zanetti R, De Angelis R. A method to estimate mortality trends when death certificates are imprecisely coded: an application to cervical cancer in Italy. Int J Cancer. 2009 Mar 1;124(5):1200-5.
PubMed

Ciccolallo L, Licitra L, Cantú G, Gatta G; EUROCARE Working Group. Survival from salivary glands adenoid cystic carcinoma in European populations.Oral Oncol. 2009 Aug;45(8):669-74. Epub 2008 Dec 17.PMID: 19095489
PubMed

Crocetti E, Buzzoni C, Puliti D. Breast neoplasms in Italy and Sicily. Epidemiol Prev. 2009 Jan-Apr;33(1-2 Suppl 1):87-94.
PubMed

Crocetti E; AIRTUM Working Group. Nunmbers: cancers in the very elderly. Epidemiol Prev. 2009 Nov-Dec;33(6):242.
PubMed

Crocetti E; AIRTUM Working Group. AIRTUM numbers. For which tumor classes incidence is changing faster?. Epidemiol Prev. 2009 May-Jun;33(3):78.
PubMed

Crocetti E; AIRTUM Working Group. Italy. The seven tumors with the worst prognosis. Epidemiol Prev. 2009 Jan-Apr;33(1-2):64.
PubMed

Crocetti E; AIRTUM Working Group. Numbers. Testis cancer is the most frequent neoplasia among young men. Epidemiol Prev. 2009 Jul-Oct;33(4-5):145
PubMed

Dal Maso L, Polesel J, Serraino D, Lise M, Piselli P, Falcini F, Russo A, Intrieri T, Vercelli M, Zambon P, Tagliabue G, Zanetti R, Federico M, Limina RM, Mangone L, De Lisi V, Stracci F, Ferretti S, Piffer S, Budroni M, Donato A, Giacomin A, Bellù F, Fusco M, Madeddu A, Vitarelli S, Tessandori R, Tumino R, Suligoi B, Franceschi S; Cancer and AIDS Registries Linkage (CARL) Study. Pattern of cancer risk in persons with AIDS in Italy in the HAART era. Br J Cancer. 2009 Mar 10;100(5):840-7.
PubMed

De Angelis R, Francisci S, Baili P, Marchesi F, Roazzi P, Belot A, Crocetti E, Pury P, Knijn A, Coleman M, Capocaccia R; EUROCARE Working Group. The EUROCARE-4 database on cancer survival in Europe: data standardisation, quality control and methods of statistical analysis. Eur J Cancer. 2009 Apr;45(6):909-30. Epub 2009 Jan 6.
PubMed

Crocetti E, Buzzoni C. New incidence and mortality data. 2003-2005. Epidemiol Prev. 2009 Apr 23;33(1-2 Suppl 2).
PubMed

Crocetti E, Guzzinati S, Paci E, Falcini F, Zanetti R, Vercelli M, Rashid I, De Lisi V, Russo A, Vitarelli S, Ferretti S, Mangone L, Cesaraccio R, Tumino R, Busco S, Buzzoni C. Strong seasonality in the diagnosis of skin melanoma in Italy: the Italian Network of Cancer Registries (AIRTUM) study. Tumori. 2009 Nov-Dec;95(6):665-8.
PubMed

Ferretti S, Guzzinati S, Zambon P, Manneschi G, Crocetti E, Falcini F, Giorgetti S, Cirilli C, Pirani M, Mangone L, Di Felice E, Del Lisi V, Sgargi P, Buzzoni C, Russo A, Paci E. Cancer incidence estimation by hospital discharge flow as compared with cancer registries data. Epidemiol Prev. 2009 Jul-Oct;33(4-5):147-53.
PubMed

Francisci S, Capocaccia R, Grande E, Santaquilani M, Simonetti A, Allemani C, Gatta G, Sant M, Zigon G, Bray F, Janssen-Heijnen M; EUROCARE Working Group. The cure of cancer: a European perspective. Eur J Cancer. 2009 Apr;45(6):1067-79. Epub 2009 Jan 7
PubMed

Gatta G, Bimbi G, Ciccolallo L, Zigon G, Cantú G; EUROCARE Working Group. Survival for ethmoid sinus adenocarcinoma in European populations. Acta Oncol. 2009;48(7):992-8.PMID: 19363711
PubMed

Gatta G, Zigon G, Capocaccia R, Coebergh JW, Desandes E, Kaatsch P, Pastore G, Peris-Bonet R, Stiller CA; EUROCARE Working Group. Survival of European children and young adults with cancer diagnosed 1995-2002. Eur J Cancer. 2009 Apr;45(6):992-1005. Epub 2009 Feb 21.
PubMed

Gondos A, Bray F, Hakulinen T, Brenner H; EUNICE Survival Working Group. Trends in cancer survival in 11 European populations from 1990 to 2009: a model-based analysis. Ann Oncol. 2009 Mar;20(3):564-73. Epub 2008 Dec 9.
PubMed

Micheli A, Ciampichini R, Oberaigner W, Ciccolallo L, de Vries E, Izarzugaza I, Zambon P, Gatta G, De Angelis R; EUROCARE Working Group. The advantage of women in cancer survival: an analysis of EUROCARE-4 data. Eur J Cancer. 2009 Apr;45(6):1017-27. Epub 2008 Dec 26.
PubMed

Puliti D, Zappa M, Miccinesi G, Falini P, Crocetti E, Paci E. An estimate of overdiagnosis 15 years after the start of mammographic screening in Florence. Eur J Cancer 2009
PubMed

Quaglia A, Tavilla A, Shack L, Brenner H, Janssen-Heijnen M, Allemani C, Colonna M, Grande E, Grosclaude P, Vercelli M; EUROCARE Working Group. The cancer survival gap between elderly and middle-aged patients in Europe is widening. Eur J Cancer. 2009 Apr;45(6):1006-16. Epub 2008 Dec 31.
PubMed

Rosso S, De Angelis R, Ciccolallo L, Carrani E, Soerjomataram I, Grande E, Zigon G, Brenner H; EUROCARE Working Group. Multiple tumours in survival estimates. Eur J Cancer. 2009 Apr;45(6):1080-94. Epub 2009 Jan 2
PubMed

Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R; EUROCARE Working Group. EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary. Eur J Cancer. 2009 Apr;45(6):931-91. Epub 2009 Jan 24.
PubMed

Schröder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, Kwiatkowski M, Lujan M, Lilja H, Zappa M, Denis LJ, Recker F, Berenguer A, Määttänen L, Bangma CH, Aus G, Villers A, Rebillard X, van der Kwast T, Blijenberg BG, Moss SM, de Koning HJ, Auvinen A; ERSPC Investigators. Screening and prostate-cancer mortality in a randomized European study. N Engl J Med. 2009 Mar 26;360(13):1320-8.
PubMed

Verdecchia A, Guzzinati S, Francisci S, De Angelis R, Bray F, Allemani C, Tavilla A, Santaquilani M, Sant M; EUROCARE Working Group. Survival trends in European cancer patients diagnosed from 1988 to 1999. Eur J Cancer. 2009 Apr;45(6):1042-66. Epub 2009 Jan 3
PubMed


www.ispo.toscana.it

- 2008 Tutti i diritti riservati I.S.P.O. - .: designed by: blucomunicazione.com :.